The Longevity Stack is a mitochondria-first approach to addressing hallmarks of aging. It combines peptides that target mitochondrial function (MOTS-c, SS-31), telomere biology (Epitalon), and NAD+ metabolism (NMN) — along with a foundational supplement base.
This protocol is derived from longevity research literature and the biohacking community. The rationale is that aging is driven by convergent mechanisms — targeting multiple pathways simultaneously may produce additive or synergistic effects.
| Hallmark | Compound | Mechanism |
|---|---|---|
| Mitochondrial dysfunction | MOTS-c, SS-31 | AMPK activation, mitochondrial membrane protection |
| Telomere shortening | Epitalon | Telomerase activation, pineal gland regulation |
| NAD+ decline | NMN | NAD+ precursor; supports sirtuin activity |
| Chronic inflammation | MOTS-c, SS-31 | NF-κB modulation, ROS reduction |
| Metabolic dysregulation | MOTS-c | Insulin sensitization, AMPK activation |
Mitochondria-derived peptide. AMPK activator, insulin sensitizer, exercise mimetic.
Longevity InjectableTetrapeptide. Studied for telomerase activation and pineal gland / circadian rhythm support.
Longevity Injectable/NasalMitochondria-targeted antioxidant. Protects mitochondrial membranes, reduces oxidative stress.
Mitochondrial InjectableNicotinamide mononucleotide. NAD+ precursor supporting sirtuin activity and cellular energy.
Oral SupplementRanges below are from animal research and community self-experimentation literature. NOT dosing recommendations.
| Compound | Research Range | Frequency | Route |
|---|---|---|---|
| MOTS-c | 5–10 mg/week | 2–3x/week | SubQ |
| Epitalon | 5–10 mg/day | Daily (10-day cycles) | SubQ / Nasal |
| SS-31 | 1–5 mg/day | Daily or EOD | SubQ |
| NMN | 250–1000 mg/day | Daily | Oral |
Epitalon is commonly cycled: 10 days on, then a long off period (1–6 months). MOTS-c and SS-31 are used in 4–8 week cycles with equal off periods.
Affiliate links — we may earn a commission. Always verify COAs.