Educational Use Only: BPC-157 is a research compound not approved for human therapeutic use. This profile is for informational purposes only. It does not constitute medical advice. Consult a qualified healthcare professional before making any health decisions.
Overview
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids. It is derived from a partial sequence of a protein found in human gastric juice. BPC-157 has been studied extensively in animal models for its regenerative and cytoprotective properties.
It is one of the most widely studied research peptides in the biohacking community, commonly used in conjunction with TB-500 as part of a "Wolverine" healing stack.
Mechanism of Action
BPC-157 operates through multiple pathways:
- Nitric oxide system: Modulates NO synthesis, contributing to vasodilation and angiogenesis
- Growth factor upregulation: Stimulates expression of VEGF, EGF, and PDGF receptor signaling
- Tendon fibroblast activity: Increases proliferation of tendon fibroblasts, accelerating tendon repair
- Gut mucosal protection: Protects gastric mucosa from NSAID-induced damage; promotes intestinal anastomosis healing
- Inflammatory modulation: Reduces pro-inflammatory cytokines without significant immunosuppression
Research Summary
| Area | Finding | Evidence Level |
|---|
| Tendon healing | Significantly accelerated Achilles tendon repair in rats | Animal models |
| Muscle repair | Improved healing of transected muscle in rodents | Animal models |
| Gut health | Protects against NSAID-induced gastric lesions | Animal models |
| Bone healing | Accelerated segmental bone defect repair | Animal models |
| CNS protection | Neuroprotective effects following traumatic brain injury in rats | Animal models |
| Human use | No completed human clinical trials as of 2026 | No human data |
Pharmacokinetics
- Half-life: Approximately 4 hours when administered subcutaneously
- Bioavailability: Higher with subcutaneous or intramuscular injection; oral bioavailability studied but lower
- Distribution: Systemic distribution; crosses blood-brain barrier in animal studies
- Elimination: Renal clearance; peptide degradation via proteases
Storage & Reconstitution
- Lyophilized (powder): Store at -20°C; stable for 24+ months
- Reconstituted: Store at 4°C; use within 30 days; avoid freeze-thaw cycles
- Reconstitution solvent: Bacteriostatic water (preferred) or sterile saline
- Light sensitivity: Protect from light; store in amber vials when possible
Common Stacks
BPC-157 is frequently paired with other compounds in research protocols:
- BPC-157 + TB-500 — The "Wolverine Stack." Complementary mechanisms: BPC-157 targets local tissue repair while TB-500 promotes systemic actin regulation and angiogenesis.
- BPC-157 + GHK-Cu — Combined tissue repair and collagen synthesis support.
- BPC-157 alone — Used for localized injection near injured tissue areas (animal research).
View the full Wolverine Protocol →
Sourcing
Verified Vendors Carrying BPC-157
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Coupon: ROCN
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