Educational Use Only: TB-500 is a research compound. This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional.
Overview
TB-500 is a synthetic fragment of Thymosin Beta-4 (Tβ4), specifically the actin-binding domain sequence. Thymosin Beta-4 is a naturally occurring 43-amino acid peptide found throughout the body, particularly in blood platelets and wound fluid. TB-500 has been studied for its role in promoting tissue repair, reducing inflammation, and enhancing cellular migration.
Mechanism of Action
- Actin regulation: Sequesters G-actin monomers, influencing cellular motility and differentiation
- Angiogenesis: Promotes new blood vessel formation, improving blood supply to injured tissue
- Anti-inflammatory: Downregulates inflammatory cytokines including IL-1 and TNF-alpha
- Stem cell differentiation: Promotes differentiation of progenitor cells toward cardiac and muscle lineages in animal models
- Hair follicle stimulation: Activates hair follicle stem cells in preliminary research
Research Summary
| Area | Finding | Evidence Level |
|---|
| Cardiac repair | Regenerated cardiac muscle after infarction in mouse models | Animal models |
| Wound healing | Accelerated wound closure and reduced scarring | Animal models |
| Corneal healing | Phase II trials show improved healing of corneal injury | Human (Phase II) |
| Muscle repair | Improved recovery from muscle crush injuries in rats | Animal models |
| Neuroregeneration | Improved functional recovery after spinal cord injury in rats | Animal models |
Pharmacokinetics
- Half-life: Several days when administered subcutaneously — longer acting than BPC-157
- Distribution: Systemic; concentrates in areas of injury
- Elimination: Proteolytic degradation; renal clearance of fragments
Storage & Reconstitution
- Lyophilized: Store at -20°C; stable for 2+ years
- Reconstituted: Store at 4°C; use within 30 days
- Solvent: Bacteriostatic water preferred
- Light: Protect from UV light
Common Stacks
- TB-500 + BPC-157 — Wolverine Stack. BPC-157 for local acute repair, TB-500 for systemic regeneration and angiogenesis.
- TB-500 alone — Used in longer dosing cycles due to longer half-life (e.g., 2x/week loading, 1x/week maintenance).
View the Wolverine Protocol →
Sourcing
Verified Vendors Carrying TB-500
EliteBiogenix ✓ Verified
Coupon: ROCN
Visit ↗
Affiliate link — we may earn a commission.